Also known as microspikes, Filopodia are slender projections that extend from the different areas of cells that undergo migration. They form adhesions with the help of the substratum that provides in building their linkage with the cell surface of migrating cells. With the help and presence of Filopodia many cells are provided with the ability of undergoing greater locomotion through the chemotropic and thermo tropic changes that take place within the cell vicinity.
However during the course of this discussion we would be restricting our scope of discussion to retroviruses that can spread between cells by making use of filopial bridges. The different researches and studies that has been conducted in this context proves that the magnitude and the rate of spread of diseases by the retroviruses enhances substantially when cells can physically interact with each other which is mainly responsible through the help of Filopodia. (Artmann, 2010)
Further analysis and research proves that with the help of filopodial bridges retroviruses can spread from infected to non-infected cells and from cells to tissues which are ultimately dependent upon the cells for their nutrition and sustenance. These filopodia mainly originate from non-infected cells and cause a mutual interaction with the infected cells with the help of their tips.
Upon research it can easily be found out that a strong association of a viral envelope glycoprotein known as Env generates a stable bridge with the help of filopodial bridges to facilitate the entry of a virus from an infected to a non-infected cell.
Furthermore it is also suggestive from the data that many of the retroviruses are able to spread themselves from one part of the body to the other through the exploitation of the inherent capability of filopodia which is the enable the transport of ligands from one cell to the other. (Nathan, 2007)